low cytotoxicity — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7057	Methylstat		Histone Demethylase , Others
	Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD...		Histone Demethylase , Others
T22381	Antimalarial agent 14	4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone	Others
	Antimalarial agent 14 (NSC-102533) is a bioactive chemical.		Others
T6256	YYA-021	YYA 021	gp120/CD4 , HIV Protease
	YYA-021 inhibits HIV entry, with high anti-HIV activity and low cytotoxicity.		gp120/CD4 , HIV Protease
T7293	EC330		Others
	EC330, a novel steroidal LIF inhibitor showed cytotoxicity in various cancer cell lines and NCI-60 cell line panel at low nano-molar range.		Others
T77631	Enpp/Carbonic anhydrase-IN-2		Apoptosis , PDE , Carbonic Anhydrase
	Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-I...		Apoptosis , PDE , Carbonic Anhydrase
T73556	CZL55		Caspase
	CZL55 is a potent caspase-1 inhibitor with an IC50 value of 0.024 μM.CZL55 has low cytotoxicity and can be used in the study of febrile seizures (FS).		Caspase
T15621	Rilematovir	JNJ-53718678,JNJ-678	EGFR , RSV
	Rilematovir (JNJ-678) is an inhibitor of fusion protein with antiviral activity and low cytotoxicity. Rilematovir can be used in studies about respiratory syncytial virus treatment.		EGFR , RSV
T35340	Bictegravir Sodium	GS-9883 Sodium	HIV Protease
	Bictegravir Sodium (GS-9883 Sodium) is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir Sodium exhibits potent and selective anti-HIV activity and low cytotoxicity		HIV Protease
TN2331	Eleutheroside B1		Influenza Virus
	Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits l...		Influenza Virus
T9088	Topovale	ARC111,ARC 111,ARC-111,Topoval	Topoisomerase
	Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topo...		Topoisomerase
T60857	MKK7-COV-9		Others
	MKK7-COV-9 is a selective and potent covalent inhibitor of MKK7 with inhibitory effects on MKK7-induced protein-protein interactions.MKK7-COV-9 interrupts the activation of primary B-cells in response to LPS.MKK7-COV-9 s...		Others
T7055	Bz-RS-ISer(3-Ph)-Ome	Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate	Others , HIV Protease
	Bz-RS-ISer(3-Ph)-Ome (Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate) is a paclitaxel derivative that inhibits the HSV replication cycle at low cytotoxicity, blocks mitosis in Vero cells, affects the size o...		Others , HIV Protease
T62899	Tau-aggregation and neuroinflammation-IN-1		Microtubule Associated , NO Synthase
	Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-length tau protein aggregates. Tau-aggregation and neuroinflamma...		Microtubule Associated , NO Synthase
TN2701	2,3-Dihydroxy-12-oleanen-28-oic acid		Others
	2,3-Dihydroxy-olean-12-en-28-oic acids show a low cytotoxicity towards several human tumor cell lines.		Others
T71954	MMG-0358
	MMG-0358 is a novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme.
T61221	Antiparasitic agent-8
	Antiparasitic agent-8 (Compound 9) exhibits potent antiparasitic activity against Hymenolepis nana, while demonstrating low levels of cytotoxicity [1].
T23626	Acyclovir alaninate
	Acyclovir alanine is a pro-drug of Acyclovir. Acyclovir works by decreasing the production of DNA of the virus and it shows very low cytotoxicity.
T16123	MMG-11		Others
	MMG-11 inhibits both TLR2/1 and TLR2/6 signaling (IC50s: 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses). MMG-11 is an effective and selective human TLR2 antagonist with low cytotox...		Others
T37675	3-Deaza-2'-deoxyadenosine
	3-Deaza-2'-deoxyadenosine strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 μM. This nucleoside can also be used to evaluate the role of the adenine N3 nitrogen in DNA structure an...
T61737	FtsZ-IN-4
	FtsZ-IN-4, an orally active inhibitor of FtsZ (filamenting temperature-sensitive mutant Z), demonstrates remarkable antibacterial activity and favorable pharmaceutical properties. With low cytotoxicity (CC 50 >20 μg/mL) ...